Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1130 | Endocrine tumours | ECE2015

PATZ1 downregulation promotes proliferation and migration in Ras-driven thyroid transformation

Vitiello Michela , Valentino Teresa , Menna Marta De , Francesca Paola , Vita Gabriella De , Fedele Monica

Thyroid cancer is one of the most frequent malignancies of the endocrine system, and its incidence is predicted to become the fourth leading cancer diagnosis by 2030. Among thyroid carcinomas, anaplastic thyroid cancer (ATC) is the most aggressive and lethal tumor, which grows very rapidly, invades adjacent tissues and metastasizes, causing death in 1 year from diagnosis. We recently showed that in thyroid cancer PATZ1 expression is downregulated compared to normal thyroid and...